New: BRCAvantage™: BRCA1 and BRCA2 Genetic Testing for Hereditary Breast and Ovarian Cancer Risk
According to the American Cancer Society, 5% to 10% of breast cancer cases are thought to be hereditary, resulting directly from gene mutations inherited from a parent. The most common cause of hereditary breast cancer is an inherited mutation in the BRCA1 and BRCA2 genes. ¹
Compared to the general population, women with a confirmed BRCA mutation have a greatly increased risk of developing cancer during their lifetime—up to an 85% risk for breast cancer and up to a 40% risk for ovarian cancer. Their children, brothers, sisters, and parents have a 50% chance of possessing the same autosomal dominant mutation and facing comparable risks.2
Through our relationship with Quest Diagnostics, CompuNet offers four lab-developed genetic tests (LDT) that identify mutations in BRCA1 and BRCA2 genes, associated with increased susceptibility for developing breast, ovarian, and some other cancers.
A BRCA genetic evaluation is recommended when:
- There is a personal or family history of known BRCA mutation
- Individual has had ovarian cancer
- Individual has had breast cancer with one or more of the following:
- diagnosed at ≤50 years of age
- is Ashkenazi Jewish
- has bilateral breast cancer
- has triple negative breast cancer
- has male breast cancer
- has personal or family history of ovarian, pancreatic, prostate, sarcoma, adrenocortical, brain, endometrial, thyroid, leukemia, lymphoma, or diffuse gastric cancer
- Two people on the same side of the family have had breast cancer
BRCA1 and BRCA2 Test Options
- BRCAvantage™ Comprehensive Evaluation (BRCA1 seq, BRCA1 dup/del, BRCA2 seq, BRCA2 dup/del)
- BRCAvantage™ Ashkenazi Jewish Evaluation (specific mutations to Ashkenazi population in BRCA1 and BRCA2)
- BRCAvantage™ Single Site/Known Familial Variant (selected mutation in BRCA1 or BRCA2)
- BRCAvantage™ Rearrangement Evaluation (BRCA1 dup/del and BRCA2 dup/del)
Genetic counseling is an important part of BRCA testing. For physicians, Quest Diagnostics offers consultations to answer questions related to genetic testing and test selection. Many patients already have access to genetic counseling services through their primary healthcare provider. For those who don’t, Quest Diagnostics will link individuals considering genetic testing to a genetic counselor. Counselors will advise on benefits, limitations, risks and options associated with testing, and they will help explain what the results mean for the patient and the patient’s family. For a genetic consultation, please call (866) GENE-INFO.
Alternatively, if you’d like to search your area for a genetic counselor, we recommend checking the National Society of Genetic Counselors’ website.
Quest Diagnostics offers a concierge insurance preauthorization service prior to testing. Many insurance plans have established specific criteria in order to cover and reimburse the cost of BRCA testing. We will work with health plans on your behalf to determine if the test will be covered to help inform the patient decision on ordering or moving forward with testing. For information on preauthorization services, please call (866) GENE-INFO.
¹ American Cancer Society BRCA Information - http://www.cancer.org/cancer/breastcancer/moreinformation/breastcancerearlydetection/breast-cancer-early-detection-risk-factors-you-cannot-change. Accessed December 10, 2013.
2 Cancer.Net. American Society of Clinical Oncology (ASCO). Cancer.Net Editorial Board, Feb 2010. Available from: http://www.cancer.net/cancer-types/hereditary-breast-and-ovarian-cancer. Accessed December 10, 2013.
Prescription Drug Monitoring
Also known as Pain Management, this program can help healthcare providers identify patients who are not taking their pain medications as directed.
Prescription drug misuse occurs in all types of patients:
- Patients who fail to follow their prescriber’s instructions
- Patients who share their prescription drugs with friends and family
- Patients who forget to report drugs prescribed by other physicians
- Patients who mix their prescription drugs with substances of abuse or with other non-prescribed drugs
- Drug diverters who share or sell drugs to others
- Drug addicts who seek drugs for their own use
- Doctor “shoppers” who seek duplicate pain prescriptions from multiple, unknowing physicians
- Click to view video, authored by Robert Stutman - former Special Agent from the U.S. Drug Enforcement Agency, "Prescription Drugs in America 2011: Are We Really Doing No Harm?"
- Click to view video, "Prescription Drug Abuse - Real Physicians Speak Out".
Nearly three out of four people who misuse prescription pain medications are taking drugs that were prescribed for someone else.¹
¹SAMHSA, Results from the 2010 National Survey on Drug Use and Health: Summary of National Findings. NSDUH Series H-41, HHS Publication No. (SMA) 11-4658. Rockville, MD: Substance Abuse and Mental Health Services Administration, 2011.
Taking the following steps may help lessen your risk:
- Conduct a psychological assessment on patients to include a screening for risk of addictive behaviors
- Adopt a patient-physician opioid treatment agreement
- Monitor Ohio’s state pharmacy database
- Adhere to any local prescription drug management regulations
- Regularly assess patients for adverse side effects, aberrant behavior, prescription drug treatment effects, and adherence to the prescription drug treatment through urine drug testing
CompuNet’s Rx Drug Monitoring program offers:
- A menu specifically designed for prescription drug testing
- A Urine Drug Testing program with an easy-to-use collection cup to help identify potential tampering.
- A medMATCH™ report which compares the presence of drug metabolites to the drugs that are being prescribed for the patient
- A toxicology hotline through Quest Diagnostics; Toxicology Consultant Specialists are available Monday – Friday, 8:00 AM to 6:00 PM. To contact the RX TOX hotline call: 1-877-40-RX TOX
Advanced Cardiovascular Testing
According to the CDC’s most recent statistics, heart disease remains the #1 leading cause of death for both men and women in the U.S.¹ In a major study, it was found that 50% of people who suffered a cardiovascular event had normal cholesterol levels.²
2Cromwell WC et al. Am J Cardiol 2006;98: 1599-1602.
CompuNet provides options—beyond the standard cholesterol test—to help you assess your patients’ cardiovascular event risks.
Patients with the following risk factors could benefit from advanced lipid testing:
Diabetes, Metabolic syndrome, family history of heart disease, previous history of heart attack, high blood pressure, overweight/obese, low HDL, high triglycerides